A method for real-time collimation and ROI-filter positioning in X-ray imaging in interventional procedures includes acquiring an image of a region-of-interest (ROI) at a beginning of a medical intervention procedure on a subject, classifying the image based on low-level features in the image to determine a type of procedure being performed, determining a list of landmarks in the image from the type of procedure being performed, and loading a pre-trained landmark model for each landmark in the list of landmarks, where landmarks include anatomical structures of the subject and medical devices being used in the medical intervention procedure, and computing collimator settings of an X-ray imaging device from ROI filter margins and bounding boxes of the landmarks calculated using the landmark models.
