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PROCÉDÉ D'ÉVALUATION DE COMPRIMÉ À DÉSINTÉGRATION ORALE ET DISPOSITIF D'ÉVALUATION DE COMPRIMÉ À DÉSINTÉGRATION ORALE
专利权人:
LTD.;SAWAI PHARMACEUTICAL CO.;沢井製薬株式会社;SAWAI PHARMACEUTICAL CO., LTD.
发明人:
NAKATANI Masatoshi,中谷匡利,SUGITA Masaru,杉田優,IKEJI Nobuaki,池治宣晃,NOZAWA Kenji,野沢健児
申请号:
JPJP2017/016529
公开号:
WO2017/188311A1
申请日:
2017.04.26
申请国别(地区):
JP
年份:
2017
代理人:
摘要:
Provided is an evaluating method capable of appropriately evaluating a degree of disintegration of an orally disintegrating tablet irrespective of the prescription system. Also provided is an evaluating device capable of appropriately evaluating a degree of disintegration of an orally disintegrating tablet irrespective of the prescription system. The method of evaluating an orally disintegrating tablet according to one mode of embodiment of the present invention includes: measuring the mass of the orally disintegrating tablet; placing the orally disintegrating tablet on a preparation placement surface of a test solution supply unit; measuring a water absorption time for a test solution to penetrate from one end of the orally disintegrating tablet in contact with the preparation placement surface to the other end of the orally disintegrating tablet; measuring the mass of the orally disintegrating tablet for which the time for the test solution to penetrate has been measured; and calculating a water absorption rate of the orally disintegrating tablet from the following formula (1); wherein the water absorption rate of the orally disintegrating tablet is evaluated relative to a water absorption rate of 0.004 g/sec.[Formula 1] Water absorption rate of orally disintegrating tablet = (mass of orally disintegrating tablet after measurement of time for test solution to be absorbed - mass of orally disintegrating tablet before measurement of time for test solution to be absorbed) / time for test solution to penetrate from one end to other end of orally disintegrating tablet (1)La présente invention concerne un procédé d'évaluation capable d'évaluer de manière appropriée le degré de désintégration d'un comprimé à désintégration orale indépendamment du système de prescription. L'invention concerne en outre un dispositif d'évaluation permettant d'évaluer de manière appropriée le degré de désintégration d'un comprimé à désintégration orale indépendamment du système de prescrip
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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