Purification of iduronate-2-sulfatase

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专利权人:

SHIRE HUMAN GENETIC THERAPIES INC.

发明人:

Nichols Dave

申请号：

NZ70309313

公开号：

NZ703093A

申请日:

2013.06.28

申请国别(地区):

NZ

年份:

2017

代理人:

摘要：

The present invention relates to a composition comprising purified recombinant iduronate-2-sulfatase (I2S) having the amino acid sequence of SEQ ID NO:1, wherein the purified recombinant I2S comprises at least 70% conversion of the cysteine residue corresponding to Cys59 of SEQ ID NO:1 to Cα-formylglycine (FGly), wherein the purified recombinant I2S contains less than 150 ng/mg Host Cell Protein (HCP).

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