COMPOSITIONS AND METHODS FOR ENHANCING RED BLOOD CELL STORAGE TIME AND SURVIVABILITY USING NITRIC OXIDE RELEASING HYBRID HYDROGEL NANOPARTICLES

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专利权人:

发明人:

Joel M. FRIEDMAN,Pedro CABRALES,Adam J. FRIEDMAN

申请号：

US15312080

公开号：

US20170105407A1

申请日:

2015.05.21

申请国别(地区):

US

年份:

2017

代理人:

摘要：

Described herein are hydrogel-based nanoparticles which release nitric oxide (NO) or other bioactive forms of NO including nitrosothiols, nitrofatty acids and dinitrogen trioxide into stored red blood cells (RBCs). Also provided herein is a method for using hydrogel-based nanoparticles to supplement stored RBCs with NO to enhance red blood cell (RBC) storage time, improve survivability in circulation, minimize toxicity associated with transfusion, and improve transfusion safety by eliminating infective organisms in stored blood.

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中国工程科技知识中心

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