Indiana University Research and Technology Corporation
发明人:
Ching-Pin Chang,Jin Yang
申请号：
US15500161
公开号：
US20170266253A1
申请日:
2015.07.31
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Methods are disclosed herein for administering a FoxM1 inhibitor for preventing, treating, and/or reducing cardiac hypertrophy and/or cardiac failure. Particularly, the methods are directed to the use of a FoxM1 inhibitor to block the function of FoxM1-Brg1 complex, thereby reversing the ACE/ACE2 expression ratio such to protect the heart from hypertrophy and failure.
