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QUINOLIZIDINE AND INDOLIZIDINE DERIVATIVES
专利权人:
F. HOFFMANN-LA ROCHE AG
发明人:
KOLCZEWSKI SABINE,PINARD EMMANUEL
申请号:
ZA201209089
公开号:
ZA201209089B
申请日:
2012.11.30
申请国别(地区):
ZA
年份:
2013
代理人:
摘要:
The present invention relates to a compound of formula I-A or I-B wherein X, R1, R2 and R3 are defined herein; or to a pharmaceutically acceptable acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer thereof. The compounds of formulas I-A and I-B are good inhibitors of the glycine transporter 1 (GlyT-1), and have a good selectivity to glycine transporter 2 (GlyT-2) inhibitors, suitable in the treatment of neurological and neuropsychiatric disorders.
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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