The present invention relates to a composite prosthesis including a coated mesh having at least one opening through a first surface and a second surface of the coated mesh the coated mesh comprising a mesh and a biocompatible coating substantially surrounding each filament of the mesh, wherein the biocompatible coating is formed by coating the mesh with a polyol prepolymer and curing the prepolymer, the prepolymer comprising a polyalkylene oxide polyol end capped with isocyanate, the polyalkylene oxide polyol having from about 70% to about 95% ethylene oxide groups and the remainder propylene oxide and a barrier material comprising a biocompatible membrane constructed and arranged to cover at least one surface of the coated mesh, wherein the barrier material comprises a biologic material.
