Method of making a composition with low dissolved oxygen content, containing acetaminophen and optionally one or more NSAIDs, and composition obtained thereby
The invention is a method of making an aqueous composition for intravenous administration comprising acetaminophen and optionally one or more non-steroidal anti-inflammatory drugs (NSAIDs), the dissolved oxygen of the composition in a sealed container. Is up to 1.0 ppm and the method heats the tube by rinsing the compound tube at least once with water at a temperature of at least 80° C. to create a hypoxic environment in the tube and in the rinsed tube. Dissolving acetaminophen in water for injection, wherein said water for injection is at a temperature of at least 80° C. and optionally adding one or more NSAIDs before or after dissolution of acetaminophen. .. [Selection diagram] None本発明は、アセトアミノフェンと、任意に1つ以上の非ステロイド系抗炎症薬（NSAID）とを含む静脈内投与用水性組成物を作製する方法であって、密閉容器における組成物の溶存酸素が最大1.0 ppmであり、該方法が、少なくとも80℃の温度の水で化合管を少なくとも1回すすぐことにより該管を加熱し、該管において低酸素環境を作り出すことと、上記すすいだ管において注射用水にアセトアミノフェンを溶解させることとを含み、上記注射用水が少なくとも80℃の温度であり、アセトアミノフェンの溶解前又は溶解後に任意に1つ以上のNSAIDを添加する、方法を提供する。【選択図】なし
