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method of treating proliferative disorders and other pathological conditions mediated by bcr-abl, c-kit, ddr1, ddr2 or pdgf-r kinase activity
专利权人:
NOVARTIS AG
发明人:
Ophelia Yin,Richard Woodman,Tomasz Szczudlo
申请号:
BR112012009094
公开号:
BR112012009094A8
申请日:
2010.10.21
申请国别(地区):
BR
年份:
2017
代理人:
摘要:
method of arresting proliferative disorders and other pathological conditions mediated by bcr-abl, c-kit, ddr1, ddr2 or pdgf-r kinase activity The present invention relates to a regimen for the administration of a pyrimidylaminobenzamide of formula I as defined herein for the treatment of proliferative disorders, particularly solid and liquid tumors, and other pathological conditions mediated by bcr-abl oncoprotein, the c-kit cell transmembrane tyrosine kinase receptor, ddr1 (discoidine domain receptor 1), ddr2 (discoidine domain receptor) 2) or pdgf-r (platelet derived growth factor receptor) kinase activity.método de travamento de transtornos proliferativos e outras condições patológicas mediadas por bcr-abl, c-kit, ddr1,ddr2 ou atividade pdgf-r quinase a presente invenção refere-se a um regime para a administração de uma pirimidilaminobenzamida de fórmula l conforme aqui definida para o tratamento de transtornos proliferativos , particularmente tumores sólidos e líquidos , e outras condições patológicas mediadas pela oncoproteína bcr-abl, o receptor de tirosina quinase transmembrana celular c-kit , ddr1 ( receptor de domínio discoidiina 1), ddr2 (receptor de domínio discoidina 2) ou atividade pdgf-r (receptor de fator de crescimento derivado de plaquetas ) quinase.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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