GANGAKHEDKAR, ARCHANA,DAI, XUEDONG,ZERANGUE, NOA,VIRSIK, PETER A.
申请号：
CA2806444
公开号：
CA2806444C
申请日:
2009.08.19
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
Compounds of Formula (II) are provided:(see formula II)or a pharmaceutically acceptable salt thereof, wherein:R6 is C1-6 alkyl, substituted C1-6 alkyl, C1-6 heteroalkyl, substituted C1-6heteroalkyl, C3-8cycloalkyl, substituted C3-8 cycloalkyl, C6-8 aryl, substituted C6-8 aryl, or¨OR10；wherein R16 is C1-6 alkyl, substituted C1-6 alkyl, C3-10 cycloalkyl,substituted C3-10cycloalkyl, C6-10 aryl, or substituted C6-10 aryl；R7 and R8 are independently hydrogen, C1-6 alkyl, or substituted C1-6 alkyl；andR9 is methyl；wherein each substituent group is independently, ¨OH, ¨CN, ¨CF3, =O, ¨NO2,benzyl, ¨C(O)NR11 2, ¨R11, -OR11, ¨C(O)R11, -COOR11, or¨NR11 2wherein each R11 is independently hydrogen or C1-4 alkyl. Pharmaceuticalcompositionscomprising compounds of Formula II, and methods of using compounds of FormulaIIand pharmaceutical compositions thereof for treating diseases such aspsoriasis,asthma, multiple sclerosis, inflammatory bowel disease, and arthritis are alsodisclosed.
