LUBRIS LLC;RHODE ISLAND HOSPITAL, A LIFE SPAN PARTNER
发明人:
CHODOBSKA, Adam,ELSAID, Khaled,FAREED, Jawed,JAY, Gregory,KRAWETZ, Roman,SCHMIDT, Tannin,SULLIVAN, Benjamin,SZMYDYNGER-CHODOBSKA, Joanna,TRUITT, Edward
申请号：
TN2017000270
公开号：
TN2017000270A1
申请日:
2016.01.26
申请国别(地区):
TN
年份:
2018
代理人:
摘要：
Disclosed herein are methods of using PRG4 glycoprotein, also known as lubricin, to reduce, inhibit, or down-regulate pro-inflammatory pathways in patients at risk of or suffering from an inflammatory response or allergy symptom through CD44 antagonization, regulating pro-inflammatory cytokine production, inhibiting NF-κΒ translocation and/or facilitating removal of inflammation-inducing cellular or matrix debris or allergens.
