It consists of one component substantially, sliding characteristic liquid dense characteristic is satisfactory, is water absortion power low, the pre- filled syringe which possesses the intermediate gasket whose influence to the pH of liquid medicine is small is offered. Being the plurilocular pre- filled syringe which possesses the intermediate gasket, as from the intermediate gasket the liquid medicine is enclosed to bilocular it is basic edge side, at the same time from the intermediate gasket the powder medicine is enclosed in the aforementioned first room which is advanced side, the aforementioned intermediate gasket as it possesses two layers of the basic edge layer which reaches advanced layer and the aforementioned bilocular wall which at least become the wall of the aforementioned first room, from aforementioned advanced layer provides the layer of water absortion power low in layer of basic edge side, at the same time the aforementioned basic edge layer is low water absortion power, the material which does not decrease the pH of liquid medicineSo being formed, the pre- filled syringe which becomes.実質的に一部材で構成され、摺動性・液密性が良好であり、低吸水性であり、液剤のpHへの影響が小さい中間ガスケットを有するプレフィルドシリンジを提供する。中間ガスケットを有する複室のプレフィルドシリンジであって、中間ガスケットより基端側となる第二室には液剤が封入されると共に、中間ガスケットより先端側となる前記第一室には粉末剤が封入され、前記中間ガスケットは、少なくとも前記第一室の壁となる先端層及び前記第二室の壁となる基端層の二つの層を有するとともに、前記先端層より基端側の層に低吸水性の層を設け、且つ前記基端層は、低吸水性且つ液剤のpHを低下させない材質で形成されてなるプレフィルドシリンジ。
