Human antigen CGRP； Nucleic acid for coding； Vectors； Somatotype cells； Production methods； Pharmacological synthesis and diagnostic understanding； and therapeutic uses
KOVACEVICH BRIAN ROBERT,GARCIA-MARTINEZ LEON F,OLSON KATIE,DUTZAR BENJAMIN,BILLGREN JENS J,LATHAM JOHN A,MITCHELL DANIELLE M,MCNEILL PATRICIA DIANNE,JANSON NICOLE M,LOOMIS MARIA-CRISTINA
申请号：
CL2013003336
公开号：
CL2013003336A1
申请日:
2013.11.20
申请国别(地区):
CL
年份:
2014
代理人:
摘要：
The present invention is directed to antibodies and fragments thereof having binding specificity for CGRP. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the V, Vand CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-CGRP antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-CGRP antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-CGRP antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with CGRP.ANTICUERPO ANTI-CGRP HUMANO； ACIDO NUCLEICO QUE LO CODIFICA； VECTOR； CELULA HUESPED； METODO DE PRODUCCION； COMPOSICION FARMACEUTICA Y DIAGNOSTICA QUE LO COMPRENDE； Y SU USO TERAPÉUTICO
