LANGERMANN, SOLOMON,FLIES, DALLAS BENJAMIN,LIU, LINDA
申请号：
CA3089469
公开号：
CA3089469A1
申请日:
2019.01.23
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
Compositions and methods of use thereof for modulating B7-H4 are provided. For example, immunomodulatory agents are provided that reduce B7-H4 expression, ligand binding, crosslinking, negative signaling, or a combination thereof. Such agents can be used to increase an immune response in a subject in need thereof. Immunomodulatory agents are also provided that increase B7-H4 expression, ligand binding, crosslinking, negative signaling, or a combination thereof. Such agents can be used to reduce an immune response in a subject in need thereof.
