Roche Innovation Center Copenhagen A/S;Bristol-Myers Squibb Company
发明人:
Richard E. OLSON,Angela M. CACACE,Peter HAGEDORN,Anja Mølhart HØG,Niels Fisker NIELSEN,Dong LI,Jeffrey M. BROWN,Stephen E. MERCER,Marianne Lerbech JENSEN
申请号：
US15548390
公开号：
US20190383797A1
申请日:
2016.02.04
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present disclosure provides methods of using a calcium oscillation assay and/or a sequence score calculation to identify a molecule that is safe for administration. The disclosure also includes a method of selecting or identifying a molecule having tolerable in vivo neurotoxicity using a calcium oscillation assay, a sequence score method, an in vivo tolerability assay, or any combination thereof.
