This invention relates to a live-attenuated recombinant lumpy skin disease virus knock-out mutant, wherein the interieukin-10-like gene or a functional part of the gene has been inactivated in the viral genome. The invention specifically relates to the recombinant lumpy skin disease virus knock-out mutant, pharmaceutical compositions comprising the knock-out mutant, methods of producing the knock out mutant and uses of the knock-out mutant.
