The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein Q, G, ring A, ring B, R1, R2, R3, R4, R5, R5a, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, R20, R21, R22, R23, R24, and m are defined herein. The novel purine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. Additional embodiments relate to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.本發明係關於式(I)化合物或其醫藥學上可接受之鹽，其中Q、G、環A、環B、R1、R2、R3、R4、R5、R5a、R6、R7、R8、R9、R10、R11、R12、R13、R14、R15、R16、R17、R18、R19、R20、R21、R22、R23、R24及m在本文中定義。該等新穎嘌呤衍生物適用於治療哺乳動物之異常細胞生長，諸如癌症。其他實施例係關於含有該等化合物之醫藥組合物及使用該等化合物及組合物治療哺乳動物之異常細胞生長的方法。
