There is described inter alia a coated bead comprising: (a) a granule； (b) a first layer coated over the granule the first layer comprising a first amount of an active pharmaceutical ingredient comprising a central nervous system stimulant； and (c) a second layer coated over the first layer the second layer being present in an amount sufficient to substantially delay release of the active pharmaceutical ingredient in the first layer until after the coated bead reaches a distal intestine portion of a subject to whom the coated bead is administered； and (d) the third layer coated over the second layer the third layer comprising a second amount of the active pharmaceutical ingredient the third layer being configured to permit substantially immediate release of the active pharmaceutical ingredient comprised therein. Embodiments related to a solid oral pharmaceutical composition are also described.
