您的位置: 首页 > 农业专利 > 详情页

Derivatives of 8- (piperazin-1-yl) -1,2,3,4-tetrahydro-isoquinoline
专利权人:
Idorsia Pharmaceuticals Ltd
发明人:
CAROFF, Eva,CASTRO, Remy,KIMMERLIN, Thierry,MEYER, Emmanuel
申请号:
ES15714957
公开号:
ES2682398T3
申请日:
2015.03.23
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
A compound of Formula (I) ** Formula ** in which R1 represents heteroaryl (C1-2) alkyl, in which the heteroaryl is a monocyclic or bicyclic aromatic ring of 5 to elements containing 1, 2 or 3 heteroatoms independently selected from oxygen, nitrogen and sulfur and in which the heteroaryl is unsubstituted or monosubstituted or substituted with (C1-4) alkyl; or (C1-2) heterocyclylalkyl, in which the heterocyclyl is a monocyclic non-aromatic ring of 5 or 6 elements containing one or two nitrogen atoms that is ringed to a phenyl or pyridinyl ring and wherein the heterocyclyl is not substituted or monosubstituted or disubstituted, in which the substituents are independently selected from the group consisting of (C1-4) alkyl and oxo; R2 represents hydrogen or methyl; R3 represents aryl, wherein the aryl is a phenyl or naphthyl group, groups that are independently unsubstituted or monosubstituted or disubstituted, in which the substituents are independently selected from the group consisting of halogen, (C1-4) alkyl, (C1-4) alkoxy, fluoroalkyl (C1-2), fluoroalkoxy (C1-2) and cyano; aryl (C1-2) alkyl, wherein the aryl is a phenyl or naphthyl group, groups that are independently unsubstituted or monosubstituted with halogen; heteroaryl, in which the heteroaryl is a monocyclic or bicyclic aromatic ring of 5 to 10 elements containing 1, 2 or 3 heteroatoms independently selected from oxygen, nitrogen and sulfur and in which the heteroaryl is unsubstituted or monosubstituted or disubstituted, in which substituents are independently selected from the group consisting of halogen, (C1-4) alkyl, cycloalkyl (C3-6), alkoxy (C1-4), fluoroalkyl (C1-2), fluoroalkoxy (C1-2), dialkyl (C1-2) -amino, hydroxy, cyano, phenyl, pyridinyl and heteroaryl (C1-2) alkyl, wherein the heteroaryl is a monocyclic aromatic ring of 5 or 6 elements containing 1 or 2 heteroatoms independently selected from oxygen, nitrogen and sulfur; aryl (C1-2) alkyl sulfonyl, wherein the aryl is a phenyl or naphthyl group;
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充