A multilayer surgical graft, comprising: a first remodelable extracellular matrix sheet； a second remodelable extracellular matrix sheet； and a synthetic mesh material with a plurality of mesh openings disposed between the first remodelable extracellular matrix sheet and the second remodelable extracellular matrix sheet. The fill material may reside in each of the mesh openings. Alternatively, the first remodelable extracellular matrix sheet and the second remodelable extracellular matrix sheet may contact and be bonded to one another through the plurality of mesh openings to provide bonded regions between the first remodelable extracellular matrix sheet and the second remodelable extracellular matrix sheet.
