Daniel Larocque,Remi Palmantier,Pascale Tribout-Jover
申请号：
US13461479
公开号：
US20120321694A1
申请日:
2012.05.01
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Compositions and methods comprising or using a combination of an adjuvant such as AS01B and an antigen such as a β-amyloid antigen are provided. The compositions and methods provided are particularly useful for prevention or treatment of Alzheimers disease. Suitable β-amyloid antigens are Aβ1-5, Aβ1-6, Aβ1-7, Aβ1-10, Aβ1-14, Aβ1-15, Aβ2-7, Aβ2-8, Aβ3-7, Aβ3-8, Aβ11-16, Aβ11-17, Aβp(E)3-7, Aβp(E)3-8, Aβp(E)3-40, Aβp(E)3-42, Aβp(E)11-16, Aβp(E)11-17, Aβp(E)11-40 or Aβp(E)11-42, optionally with a protein carrier. Suitable adjuvants comprise QS21, 3D-MPL or an AGP, optionally in combination with a liposome.
