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Nowy agonista EP4
专利权人:
Ltd.;Kaken Pharmaceutical Co., Ltd.;Kaken Pharmaceutical Co.;Asahi Glass Company, Limited
发明人:
MURATA TAKAHIKO,AMAKAWA MASAHIRO,TERADAIRA SHIN,MATSUMURA YASUSHI,KONISHI KATSUHIKO
申请号:
PL11753372
公开号:
PL2545917T3
申请日:
2011.03.08
申请国别(地区):
PL
年份:
2017
代理人:
摘要:
Provided are a compound which is superior in metabolic stability, and selectively binds to an EP4 receptor, and a medicament containing same. It has been found that a compound represented by the formula (1): wherein R 1 and R 2 are each independently a hydrogen atom or a straight chain alkyl group having a carbon number of 1 - 3, R 3 is a hydrogen atom, an alkyl group having a carbon number of 1 - 4, an alkoxyalkyl group, an aryl group, a halogen atom or a haloalkyl group, or a pharmaceutically acceptable salt thereof, has, unlike known PGI 2 analogs, a selective EP4 agonist action, and therefore, a medicament containing the compound is useful for the prophylaxis and/or treatment of immune diseases, cardiovascular diseases, cardiac diseases, respiratory diseases, ophthalmic diseases, renal diseases, hepatic diseases, bone diseases, diseases of the digestive tract, neurological diseases, skin diseases and the like.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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