Kyushu University, National University Corporation;Shin Nihon Seiyaku Co., Ltd.
发明人:
申请号：
EP14786082.9
公开号：
EP2987858B1
申请日:
2014.04.17
申请国别(地区):
EP
年份:
2019
代理人:
摘要：
A modified coxsackievirus showing improved safety and/or aggressiveness to be used for oncolytic virotherapy is provided. A modified coxsackievirus showing tissue-specific suppression of proliferation and comprising a mutated genome consisting of the genome of coxsackievirus B3 wild-type (CVB3-WT) inserted with at least one polynucleotide consisting of a target sequence of tissue-specific microRNA (miRNA) is provided. The mutated genome is preferably further inserted with the region encoding GM-CSF in an expressible form.
