THE UNITED STATES OF AMERICA; AS REPRESENTED BY THE SECRETARY; DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人:
COLLINS, PETER,LIANG, BO,MUNIR, SHIRIN,NUTT, ANNE SCHAAP,BUCHHOLZ, URSULA,MACKOW, NATALIE,KWONG, PETER,GRAHAM, BARNEY,MCLELLAN, JASON
申请号：
CA2974359
公开号：
CA2974359A1
申请日:
2016.01.20
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
Recombinant paramyxoviruses including a viral genome encoding a heterologous gene are provided. In several embodiments, the recombinant paramyxovirus is a recombinant parainfluenza virus, such as a recombinant PIV3 including a viral genome encoding a heterologous respiratory syncytial virus F ectodomain linked to the transmembrane domain and the cytoplasmic tail of the F protein from the PIV3. Nucleic acid molecules including the genome of a recombinant paramyxoviruses are also provided. The recombinant viruses may advantageously be used in vaccine formulations, such as for vaccines against parainfluenza virus and respiratory syncytial virus.
