Emil Radulescu,Sheng-Wen Huang,Ramon Erkamp,Ladislav Jankovic,Yan Shi,Khalid Shahzad
申请号：
US14007029
公开号：
US09743881B2
申请日:
2012.03.27
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Functional imaging for localization in biological tissue entails measuring a response in the tissue (240) to electromagnetic radiation. A catheter (200) for real-time monitoring of cardiac ablation is employed to distinguish a hemorrhage zone (232) from the sandwiching necrotic and healthy tissue, or to distinguish exogenous photoacoustic contrast agent from bordering native tissue. A pair of wavelengths is selected for differential absorption (244) of the radiation in, correspondingly, the hemorrhage zone or where the contrast agent exists, and relatively similar absorption elsewhere. Near infrared laser or LED light may be used photoacoustically to serially acquire (S310, S320) the two datasets to be compared, each representative of a time waveform. Alternatively, acquisition is for a pair of wavelength bands of microwave-induced thermoacoustic data. In either case, the members of the dataset pair are combined (110, 122) by subtraction or division to effect the piece-wise cancellation/enhancement for display (218) of the resulting signal in real time.
