The invention provides the antibody or its functional fragment that are specifically bound with high-affinity and PCSK9.Additionally provide the production method of the nucleic acid molecules for encoding antibody of the present invention or its functional fragment, expression vector and host cell for expressing antibody of the present invention or its functional fragment, and antibody of the present invention or its functional fragment.The invention provides the function fragment for the antibody to dyslipidemia related target and the antibody, for treating the diseases such as dyslipidemia.