Teruto Hashiguchi;Ikuro Maruyama;Salunya Tancharoen;Ko-ichi Kawahara;Kenji Tanaka;Lyang-ja Lee
发明人:
Ikuro Maruyama,Teruto Hashiguchi,Salunya Tancharoen,Ko-ichi Kawahara,Kenji Tanaka,Lyang-ja Lee
申请号：
US13635519
公开号：
US10627412B2
申请日:
2011.03.17
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention provides an inhibitor of an autoimmune response to a periodontal bacterial enzymatic degradation product of keratin in gingival epithelium in a mammal having a periodontal bacterium in the oral cavity, containing a substance having affinity to the keratin or a degradation product thereof and/or a substance having affinity to an autoantibody to the degradation product, an agent for the prophylaxis and/or treatment of a periodontal disease and/or a complication thereof； a RANKL expression inhibitor containing a substance having affinity to the keratin or a degradation product thereof； and a method of diagnosing a periodontal disease including detecting the keratin or a degradation product thereof and/or an autoantibody thereto.
