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INHIBITEUR DE CDC42 ET SES UTILISATIONS
专利权人:
ONCO BIOMEDICAL TECHNOLOGY (SUZHOU) CO.; LTD
发明人:
LU, QUN,ZHOU, HUCHEN,CHEN, YANHUA
申请号:
EP12789644
公开号:
EP2716292A4
申请日:
2012.05.21
申请国别(地区):
EP
年份:
2014
代理人:
摘要:
A compound having the structure of formula I and its use as a Cdc42 inhibitor. Morphological analyses of filopodia, western blots of Ccd42 phosphorylation, and the experiments on cellular wound healing and on growth cone formation all demonstrate that the compound provided in the present invention is able to inhibit all tested Cdc42-mediated processes. The compounds effectively inhibited the effects of Cdc42 and effectively inhibit Cdc42-related cellular functions involving actin, such as Golgi organization and cell movement.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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