A machine-implemented method including obtaining physiological signal data for a living being and performing a first analysis of the physiological signal data at a processing device local to the living being and remote from a central processing device. The method further includes transmitting from the processing device data associated with the analysis to the central processing device and performing at the central processing device a second analysis of the data associated with the first analysis. The method further includes displaying the data associated with the second analysis. The method can also include interaction between the processing device local to the living being and the central processing device. The method can also include distributing monitoring and analysis between an ambulatory and a centralized subsystem.