#$%^&*AU2011201932A120120531.pdf#####Abstract Provided are methods of treating or preventing a fungal infection in a subject. The methods comprise identifying a subject with or at risk of developing a fungal infection 5 and administering to the subject a therapeutically effective amount of an inhibitor or a fungal phosphoinositide-dependent kinase I (PDK-l) or a homolog thereof. Inhibition of the fungal PDK-l or homolog thereof results in the treatment or prevention of a fungal infection in the subject. Also provided are compositions comprising an inhibitor of a fungal phosphoinositide-dependent kinase I (PDK-1) or a homolog thereof, and a 10 pharmaceutically acceptable carrier. 15 2654839_1 (GHMatters) P87001.AU 29/04/11
