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Aza-substituted spiro derivative
- 专利权人:
- BANYU PHARMACEUTICAL CO., LTD.;MSD K.K.
- 发明人:
- JITSUOKA, MAKOTO,TSUKAHARA, DAISUKE,SATO, NAGAAKI
- 申请号：
- ES06832790
- 公开号：
- ES2381205T3
- 申请日:
- 2006.11.10
- 申请国别(地区):
- ES
- 年份:
- 2012
- 代理人:
- 摘要：
- A compound selected from the following: trans-5'-methoxy-3'-oxo-N-methyl-N- (2-piperidin-1-ylethyl) -spiro [cyclohexane-1, 1'- (3'H) - 4'-azaisobenzofuran] -4carboxamide, trans-5'-methoxy-3'-oxo-N-methyl-N- (2-pyrrolidin-1-ylethyl) -spiro [cyclohexane-1, 1'- (3'H) -4'-azaisobenzofuran] -4carboxamide, trans-4'-methoxy-3'-oxo-N-methyl-N- (2-piperidin-1-ylethyl) -spiro [cyclohexane-1, 1'- (3'H ) -5'-azaisobenzofuran] -4-carboxamide, trans-4'-methyl-3'-oxo-N-methyl-N- (2-piperidin-1-ylethyl) -spiro [cyclohexane-1, 1'- (3 ' H) -5'-azaisobenzofuran] -4-carboxamide, trans-4'- (1-methyl-1H-pyrazol-4-yl) -3'-oxo-N-methyl-N- (2-piperidin-1-ylethyl) -spiro [cyclohexane-1, 1'- (3'H) -5'-azaisobenzofuran] -4-carboxamide, and trans-5'-pyrazinyl-3'-oxo-N-methyl-N- (2-piperidin- 1-ileyl) -spiro [cyclohexane-1, 1'- (3'H) -4'-azaisobenzofuran] -4carboxamide； or one of its pharmaceutically acceptable salts.Un compuesto seleccionado de los siguientes: trans-5'-metoxi-3'-oxo-N-metil-N- (2-piperidin-1-iletil) -espiro[ciclohexano-1, 1'- (3'H) -4'-azaisobenzofuran]-4carboxamida, trans-5'-metoxi-3'-oxo-N-metil-N- (2-pirrolidin-1-iletil) -espiro[ciclohexano-1, 1'- (3'H) -4'-azaisobenzofuran]-4carboxamida, trans-4'-metoxi-3'-oxo-N-metil-N- (2-piperidin-1-iletil) -espiro[ciclohexano-1, 1'- (3'H) -5'-azaisobenzofuran]-4carboxamida, trans-4'-metil-3'-oxo-N-metil-N- (2-piperidin-1-iletil) -espiro[ciclohexano-1, 1'- (3'H) -5'-azaisobenzofuran]-4carboxamida, trans-4'- (1-metil-1H-pirazol-4-il) -3'-oxo-N-metil-N- (2-piperidin-1-iletil) -espiro[ciclohexano-1, 1'- (3'H) -5'-azaisobenzofuran] -4-carboxamida, y trans-5'-pirazinil-3'-oxo-N-metil-N- (2-piperidin-1-iletil) -espiro[ciclohexano-1, 1'- (3'H) -4'-azaisobenzofuran]-4carboxamida； o una de sus sales farmacéuticamente aceptables.
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
