Le Cong,Ann Marie Egloff,Levi A. Garraway,Jennifer Rubin Grandis,Eric S. Lander,Nicholas Stransky,Aaron D. Tward,Feng Zhang
申请号：
US13557988
公开号：
US09370551B2
申请日:
2012.07.25
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention provides methods related to the treatment of head and neck squamous cell carcinoma (HNSCC) and its associated premalignant lesions. In particular, the invention features methods which may specifically target HNSCC-associated genes and alter gene expression to treat or alleviate a symptom of HNSCC, or its related premalignant lesions. These methods may involve decreasing the function of an HNSCC-associated gene with aberrant gain-of-function or increasing the function of an HNSCC-associated gene with aberrant loss-of-function.
