New imidazolone derivatives, preparation thereof as drugs, pharmaceutical compositions, and use thereof as protein kinase inhibitors, in particular CDC7
Steinmetz, Anke,Letallec, Jean-Philippe,Bacque, Eric,Ronan, Baptiste,Conseille, Emmanuel,Leroy, Vincent
申请号：
AU2007311833
公开号：
AU2007311833B2
申请日:
2007.10.10
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
The invention relates to products of the formula (I) in which : X-Y is NH-C(S),N=C-NR7R8, N=C-SR, N=C-R or N=C-OR； R and R1 are H or optionally substituted cycloalkyl,alkyl, heterocycloalkyl, aryl or heteroaryl,； R2 is H, Hal or alkyl； R3 is H, Hal,OH, alkyl or alkoxy； R4 is H, Hal, CN or alkyl； R5 is essentially H, Hal, OH, NR7R8,cycloalkyl, alkyl, alkoxy, heterocycloalkyl, aryl or heteroaryl, optionallysubstituted； R6 is H, Hal, OH, NH2, NHalk, N(alk)2, alkyl or alkoxy； with R7 etR8 being such that one is H or optionally substituted alk, while the other is H oroptionally substituted cycloalkyl, alkyl, heterocycloalkyl, heteroarylor aryl； or with R7 and R8 forming together with N an optionally substituted cyclicradical optionally containing O, S or N. The invention also relates to isomersand salts thereof used as drugs and essentially as protein kinase inhibitors,in particular CDC7.
