New imidazolone derivatives, preparation thereof as drugs, pharmaceutical compositions, and use thereof as protein kinase inhibitors, in particular CDC7
Steinmetz, Anke,Letallec, Jean-Philippe,Bacque, Eric,Ronan, Baptiste,Conseille, Emmanuel,Leroy, Vincent
申请号:
AU2007311833
公开号:
AU2007311833B2
申请日:
2007.10.10
申请国别(地区):
AU
年份:
2013
代理人:
摘要:
The invention relates to products of the formula (I) in which : X-Y is NH-C(S),N=C-NR7R8, N=C-SR, N=C-R or N=C-OR; R and R1 are H or optionally substituted cycloalkyl,alkyl, heterocycloalkyl, aryl or heteroaryl,; R2 is H, Hal or alkyl; R3 is H, Hal,OH, alkyl or alkoxy; R4 is H, Hal, CN or alkyl; R5 is essentially H, Hal, OH, NR7R8,cycloalkyl, alkyl, alkoxy, heterocycloalkyl, aryl or heteroaryl, optionallysubstituted; R6 is H, Hal, OH, NH2, NHalk, N(alk)2, alkyl or alkoxy; with R7 etR8 being such that one is H or optionally substituted alk, while the other is H oroptionally substituted cycloalkyl, alkyl, heterocycloalkyl, heteroarylor aryl; or with R7 and R8 forming together with N an optionally substituted cyclicradical optionally containing O, S or N. The invention also relates to isomersand salts thereof used as drugs and essentially as protein kinase inhibitors,in particular CDC7.