Oral route represents the predominant and most preferable route for the administration of therapeutic agents due to its easy formulation and economic administration. However it associated with the short residence of drug which in turn reduced the efficacy. Many drugs which have narrow therapeutic window and are absorbed mainly in the upper part of gastrointestinal tract creates difficulties for oral route and possesses low bioavailability problem. Gastro retentive drug delivery may be a potential approach to overcome various issues such as short residence time, narrow therapeutic window and are absorbed mainly in upper part of gastrointestinal tract. Superporous hydrogel is the supreme approach for such categories of drug. Superporous Hydrogel, are structurally cross-linked hydrophilic polymers, which have the ability to absorb considerable amounts of water or aqueous fluids (101000 times of their original weight or volume) in relatively short periods of time. The unique property of size independent fast swelling kinetics of SPHs is accounted for by their interconnected open cellular structure. In the preparation of SPHs certain ingredients, including initiators, cross-linkers, foam stabilizers, foaming aids and foaming agents, are added into a water-diluted monomer. Good swelling and sufficient mechanical strength are the key factors that provide prolong gastric retention. So it is desirable to provide required characteristics to superporous hydrogel. Incorporation of cross linked chitosan in hydrophilic monomeric solution provides good strength to superporous hydrogel that distinguish them from conventional superporous hydrogel.
