Ki Hun Park,Jung Weon Lee,Young Bae Ryu,Hyung Won Ryu,Sin-Ae Lee
申请号：
US13482568
公开号：
US09072698B2
申请日:
2012.05.29
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to a method for screening an anticancer compound and an anticancer compound screened using the method, and more particularly, to a method for screening an anticancer compound, the method comprising: culturing cancer cells expressing the oncogenic protein transmembrane 4 L6 family member 5 (TM4SF5), expressed as the polypeptide of SEQ ID NO: 2, treating the cancer cells with an anticancer candidate, and determining that the anticancer candidate is an anticancer substance when the candidate exhibits antagonistic activity against tumor formation and metastasis based on several events through the molecular mechanism of TM4SF5. The present invention also relates to chalcone compounds screened to have anticancer activity using the method, and an anticancer composition comprising the compound as an effective ingredient.
