A pressure sensing catheter may include an elongate tubular catheter body having a first lumen extending longitudinally within the catheter body, and a second lumen extending longitudinally within the catheter body adjacent to the first lumen. Each of the first and second lumens may include proximal and distal end openings positioned at proximal and distal ends, respectively, of the catheter body. A tip portion may extend distally from the distal end of the catheter body and may include an outer wall and a tip lumen. The tip lumen may include a first and second end openings coupled to the distal end openings of the first and second lumens, respectively. The first lumen and the second lumen may be in fluid communication with one another through the tip lumen. The tip portion may be deformable in response to an external pressure applied to the outer wall of the tip portion.