A medicament for topical administration to a human or animal eye comprises atleast two pharmacologically activeagents. One of the active agents is a parasympathetic agonist, such aspilocarpine, and the other active agent is either a sympathet-icantagonist such as dapiprazole or thymoxamine, or a sympathetic agonist suchas brimonidine or iopidine. The medicament ispreferably in the form of a liquid composition, such as eye drops, or a gel orointment and may comprise a slow-release composi-tion.The medicament acts to improve visual acuity for a period of several hours,and may be beneficial in cases of presbyopia,myopia, hypermetropia, astigmatism and/or impaired night vision.
