The methods of manufacture of a drug delivery composition. In some aspects,the methods include providing an organicphase, a biologically active ingredient, and an aqueous phase with a desirablepH (e.g., a pH at which the active ingredient has increasedsolubility in the aqueous phase compared to at neutral pH). After mixing ofone or more of the aforementioned components, the resultantmixture is processed to provide the desired drug delivery composition.
