The present disclosure describes various pharmaceutical formulations and compounds for transdermal treatment of pain, neuropathy, wounds and ulcers. The formulations may be particularly useful for treating pain, diabetic neuropathy or diabetic ulcers. In one embodiment a stock cream contains the following active ingredients: about 2 w-% Nifedipine and about 3-w-% Lidocaine, about 5-12 w-% Ketamine, about 2-4 w-% amitriptyline about 8-10 w-% pentoxifylline, about 3-5 w-% mefenamic acid, and about 0.2-1 w-% clonidine. Other embodiments may exist and are contained under the purview of this disclosure.
