The General Hospital Corporation;The Charles Stark Draper Laboratory
发明人:
David M. Hoganson,Howard I. Pryor,Ira Spool,Joseph P. Vacanti,Jeffrey T. Borenstein
申请号：
US15800687
公开号：
US20180256312A1
申请日:
2017.11.01
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The invention provides method of fabricating a scaffold comprising a fluidic network, including the steps of: (a) generating an initial vascular layer for enclosing the chamber and providing fluid to the cells, the initial vascular layer having a network of channels for fluid； (b) translating the initial vascular layer into a model for fluid dynamics analysis； (c) analyzing the initial vascular layer based on desired parameters selected from the group consisting of a characteristic of a specific fluid, an input pressure, an output pressure, an overall flow rate and combinations thereof to determine sheer stress and velocity within the network of channels； (d) measuring the sheer stress and the velocity and comparing the obtained values to predetermined values； (e) determining if either of the shear stress or the velocity are greater than or less than the predetermined values, and (f) optionally modifying the initial vascular layer and repeating steps (b)-(e). The invention also provides compositions comprising a vascular layer for use in tissue lamina as well as a medical devices having a vascular layer and kits.
