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ARYL GPR120 RECEPTOR AGONISTS AND USES THEREOF
专利权人:
METABOLEX INC
发明人:
MA, JINGYUAN,NOVACK, AARON,NASHASHIBI, IMAD,PHAM, PHUONGLY,RABBAT, CHRISTOPHER J,SONG, JIANGAO,SHI, DONG FANG,ZHAO, ZUCHUN,CHOI, YUN-JUNG,CHEN, XIN
申请号:
NZ59260309
公开号:
NZ592603A
申请日:
2009.10.20
申请国别(地区):
NZ
年份:
2013
代理人:
摘要:
592603 Disclosed are aryl compounds of Formula (A) or (C) comprising a 5-membered aryl or heteroaryl ring. Specific examples of compounds of Formula (A) or (C) include: 3-(3,5-difluoro-4-((3-isopropyl-1-phenyl-1H-pyrazol-5-yl)methoxy)phenyl)propanoic acid, 2-(3,5-difluoro-4-((3-(4-fluorophenyl)-5-methylisoxazol-4-yl)methoxy)phenyl)cyclopropanecarboxylic acid, 3-(3,5-difluoro-4-((5-methyl-3-phenylisoxazol-4-yl)methoxy)phenyl)-2-methylpropanoic acid, 2-(4-((1-(4-chlorophenyl)-3-methyl-1H-pyrazol-5-yl)methoxy)-3,5-difluorobenzyl)cyclopropanecarboxylic acid, and 3-(7-((1-(4-chlorophenyl)-3-methyl-1H-pyrazol-5-yl)methoxy)-5 2,3-dihydro-1H-inden-4-yl)propanoic acid. Compounds of Formula (A) or (C) are GPR120 agonists which are useful for the treatment of metabolic diseases, including Type I and Type II diabetes and diseases associated with poor glycaemic control.
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