作為ROCK抑制劑的環狀脲類农业专利-农业学术服务平台

发明人:: SITKOFF, DOREE F.,希寇夫　朵莉Ｆ,GLUNZ, PETER W.,克劳斯　彼得Ｗ,克勞斯　彼得Ｗ,BODAS, MANDAR SHRIKRISHNA,包达斯　曼达　许克瑞许娜,包達斯　曼達　許克瑞許娜,YADAV, NAVNATH DNYANOBA,亚达夫　奈夫奈斯　黛安欧巴,亞達夫　奈夫奈斯　黛安歐巴,PATIL, SHARANABASAPPA,帕提尔　夏伦巴萨,希寇夫朵莉F,克劳斯彼得W,克勞斯彼得W,包达斯曼达许克瑞许娜,包達斯曼達許克瑞許娜,亚达夫奈夫奈斯黛安欧巴,亞達夫奈夫奈斯黛安歐巴,帕提尔夏伦巴萨

摘要：: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.本發明提供式(I)化合物：或其立體異構體、互變異構體或醫藥學上可接受之鹽，其中所有變數如本文所定義。此等化合物為選擇性ROCK抑制劑。本發明亦關於包含此等化合物之醫藥組合物及使用其治療心血管、平滑肌、腫瘤學、神經病理學、自體免疫性、纖維化及/或發炎性病症的方法。