Wouter Bult,Johannes Franciscus Wilhelmus Nijsen,Alfred Dirk van het Schip
申请号：
US13882886
公开号：
US09334298B2
申请日:
2011.11.04
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The invention is directed to a method for preparing a microsphere comprising a lanthanide metal phosphate complex, a microsphere, a powder comprising a number of the microspheres, a suspension comprising the microsphere or the powder, the use of the microsphere, a method for detecting a tumor, and a therapeutic composition comprising the microsphere, the powder, or the suspension.The invention provides a method for preparing a microsphere that comprises a lanthanide metal phosphate complex, the method comprising:(a) providing an organic lanthanide metal complex microsphere, wherein the lanthanide metal is present in an amount of more than 20 wt. %, based on total weight of the microspheres, and wherein the organic lanthanide metal complex comprises a lanthanide ion and organic ligands with which the lanthanide ion forms the complex and thereafter(b) replacing at least part of the organic ligands in the organic lanthanide metal complex microsphere with phosphate in a chimie douce reaction,wherein the lanthanide metal is present in the resulting microsphere in an amount of more than 20 wt. %, based on total weight of the microsphere, and wherein the lanthanide metal complex in the resulting microsphere comprises a lanthanide ion and phosphate.
