The present invention provides a meningococcal conjugate vaccine for groups A, C, Y and W135, which is a tetravalent conjugate vaccine comprising polysaccharide-protein conjugates obtained by respectively conjugating a capsular polysaccharide of Neisseria meningitides groups A, C, Y and W135 to a outer membrane vesicle protein selected from a group consisting of Neisseria meningitides group B serotypes 4 and 15 outer membrane vesicle proteins. The meningococcal conjugate vaccine provided by the present invention may effectively avoid the risk of affecting the immune response to vaccines resulting from immune tolerance and competition between antigenic sites existing in multivalent conjugate vaccines prepared from a single carrier protein the meningococcal conjugate vaccine provided by the present invention may avoid the safety risk of allergic reactions, toxicity reversion and the like which exist in conjugate vaccines prepared by using TT and DT as carrier proteins and the meningococcal conjugate vaccine provided by the present invention may enhance immunity to Neisseria meningitides group A and provide a bactericidal antibody having relatively extensive protective effect against Neisseria meningitides group B. Meanwhile, the present invention provides a complete production process of a meningococcal conjugate vaccine for groups A, C, Y and W135, which is applicable to large-scale production. Studies have demonstrated that the present vaccine has good immunogenicity, reliable safety and stable immunity persistence.
