Provided are a polyethylene glycol-modified angiogenesis inhibitor HM-1 and application thereof. The polyethylene glycol-modified angiogenesis inhibitor HM-1 has a sequence of mPEG-Arg-Gly-Ala-Asp-Arg-Ala-Gly-Gly-Gly-Gly-Arg-Gly-Asp, wherein mPEG can be an mPEG-SC, mPEG