A patient specific instrument (PSI) surgical guide and method for producing same is described. The method includes: obtaining imagery of at least a portion of a patient, and determining one or more surgical targets in the tissue planning at least a trajectory of the surgical procedure based on a determined surgical target within the tissue performing segmentation of the imagery creating a three-dimensional model of the PSI surgical guide, the PSI surgical guide being customized in size and shape and configured to fit on the specific patient. The PSI surgical guide is then produced to correspond to the modeled PSI surgical guide. The PSI surgical guide has a guide element positioned and oriented to guide a surgical implement along the planned trajectory toward the determined surgical target in the tissue.
