The invention refers to a synergistic combination comprising a Sigma ligand of general formula (I), and a Gabapentinoid, a medicament comprising said active substance combination, and the use of said active substance combination for the manufacture of a medicament, particularly for the prophylaxis and/or treatment of pain.本發明涉及包含通式(I)的σ配體和加巴噴丁類似物的協同組合物,包含所述活性物質組合物的藥劑,以及所述活性物質組合物用於製備藥劑的應用,特別是用於疼痛的預防和/或治療。