The present invention provides vaccine and pharmaceutical compositions for treating or preventing bacterial inventions. The vaccine compositions of the invention include a carbapenemase such as a serine carbapenemase, a metallo-β-lactamase or an immunogenic fragment thereof. The pharmaceutical compositions include an anti-carbapenemase antibody or fragment thereof. Also provided are methods for treating and preventing a bacterial infection using the vaccine and pharmaceutical compositions of the invention. The invention further provides antibody conjugates that include an antibody or fragment thereof conjugated to a siderophore or an analog thereof.本發明提供用於治療或預防細菌感染之疫苗及醫藥組合物。本發明之該等疫苗組合物包括碳青黴烯酶,例如絲胺酸碳青黴烯酶、金屬-β-內醯胺酶或其免疫原性片段。該等醫藥組合物包括抗碳青黴烯酶抗體或其片段。亦提供使用本發明之該等疫苗及醫藥組合物治療及預防細菌感染的方法。本發明進一步提供抗體偶聯物,其包括偶聯至螯鐵蛋白或其類似物之抗體或其片段。
