A method and system are presented to address quantitative assessment of spatial sequence memory in a subject, where the method comprises the steps of: (1) presenting at least one scene to the subject on a display, the scene comprising a plurality of elements and a background (2) modulating the saliency of a predetermined section of said scene (3) receiving feedback from the subject via at least one input device (4) modifying the saliency of the predetermined section (5) adjusting a functional assessment parameter relative to the scene (6) moving the predetermined section relative to the scene (7) receiving refined feedback from the subject via the input device (8) quantitatively refining the refined feedback (9) calculating a critical threshold parameter for the subject and (10) recording the critical threshold parameter onto a tangible computer readable medium.
