Problem of the present invention is that providing: a kind of immunocompetent cell, the immunocompetent cell that wherein regulatory factor immune function is expressed from immunocompetent cell combine proliferative capacity, the accumulation of the T cell of viability and ability The immunocompetent cell is prepared with Immunity regulation factor expression carrier. An immunocompetent cells have prepared expression interleukin 7 (interleukin 7), CCL19 and a kind of cell surface molecule specific recognition cancer antigen. The surface molecular specific recognition cancer antigen of this cell is preferably T cell receptor and especially identifies cancer antigen, is preferably the purposes of T cell with above-mentioned immunocompetent cell.
